Pub. Date : 2003 Jun
PMID : 12800246
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |
| 2 | AIM: To investigate the effects of melatonin (MT) on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in rat models of colitis. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |
| 3 | AIM: To investigate the effects of melatonin (MT) on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in rat models of colitis. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |
| 4 | With treatment by melatonin at the doses of 5.0 and 10.0 mg/kg(-1), CDMI in both models of rat colitis was significantly decreased (P<0.05-0.01), which accorded synchronously and unanimously with the reduced colonic NO and PGE(2) content, as well as the down-regulated expression of colonic iNOS and COX-2. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |
| 5 | CONCLUSION: Melatonin has a protective effect on colonic injury induced by both acetic acid and TNBS enemas, which is probably via a mechanism of local inhibition of iNOS and COX-2 expression in colonic mucosa. | Melatonin | nitric oxide synthase 2 | Rattus norvegicus |