Title : Galectin-3 expression in macrophages is signaled by Ras/MAP kinase pathway and up-regulated by modified lipoproteins.

Pub. Date : 2003 Jun 17

PMID : 12788225






3 Functional Relationships(s)
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1 Treatment with phorbol 12-myristate 13-acetate (PMA) increased significantly the level of expression of galectin-3 in THP-1 cells. Tetradecanoylphorbol Acetate galectin 3 Homo sapiens
2 Treatment with phorbol 12-myristate 13-acetate (PMA) increased significantly the level of expression of galectin-3 in THP-1 cells. Tetradecanoylphorbol Acetate galectin 3 Homo sapiens
3 PMA-induced galectin-3 overexpression was blocked by: protein kinase C inhibitors staurosporine, calphostin C, and apigenin; tyrosine-specific protein kinase inhibitors genistein and tyrphostin A25; PD 98059, a selective inhibitor of mitogen-activated protein kinase (MAPK) kinase 1 (MEK1 or MKK1); and SB 203580, a specific inhibitor of p38 MAPK. Tetradecanoylphorbol Acetate galectin 3 Homo sapiens