Title : Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesis.

Pub. Date : 2003 Jun 17

PMID : 12782568






1 Functional Relationships(s)
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1 METHODS AND RESULTS: In a multichannel scratch assay with human endothelial cells (ECs), HGF/SF induced a strong and prolonged activation of MAPK and cell proliferation that was inhibited by PD98059 and LY294002/wortmannin, selective inhibitors of MAPK and PI3K signaling modules, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one hepatocyte growth factor Homo sapiens