Title : T cell receptor-independent CD4 signalling: CD4-MHC class II interactions regulate intracellular calcium and cyclic AMP.

Pub. Date : 2003 Aug

PMID : 12781868






6 Functional Relationships(s)
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Protein Name
Organism
1 T cell receptor-independent CD4 signalling: CD4-MHC class II interactions regulate intracellular calcium and cyclic AMP. Cyclic AMP CD4 molecule Homo sapiens
2 T cell receptor-independent CD4 signalling: CD4-MHC class II interactions regulate intracellular calcium and cyclic AMP. Cyclic AMP CD4 molecule Homo sapiens
3 Engagement of CD4 by peptide mimetics or wild-type MHC class II, but not by mutant MHC class II molecules incapable of engaging CD4, inhibited the T cell receptor-mediated increase in cyclic AMP (cAMP) concentrations in T helper cells. Cyclic AMP CD4 molecule Homo sapiens
4 Engagement of CD4 by peptide mimetics or wild-type MHC class II, but not by mutant MHC class II molecules incapable of engaging CD4, inhibited the T cell receptor-mediated increase in cyclic AMP (cAMP) concentrations in T helper cells. Cyclic AMP CD4 molecule Homo sapiens
5 Full activation and clonal expansion of antigen-stimulated T helper cells required the CD4-mediated regulation of cyclic AMP. Cyclic AMP CD4 molecule Homo sapiens
6 Our results suggest a costimulatory mechanism of CD4 function that acts on the second messengers, calcium and cyclic AMP. Cyclic AMP CD4 molecule Homo sapiens