Pub. Date : 2003 Aug
PMID : 12781868
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | T cell receptor-independent CD4 signalling: CD4-MHC class II interactions regulate intracellular calcium and cyclic AMP. | Cyclic AMP | CD4 molecule | Homo sapiens |
| 2 | T cell receptor-independent CD4 signalling: CD4-MHC class II interactions regulate intracellular calcium and cyclic AMP. | Cyclic AMP | CD4 molecule | Homo sapiens |
| 3 | Engagement of CD4 by peptide mimetics or wild-type MHC class II, but not by mutant MHC class II molecules incapable of engaging CD4, inhibited the T cell receptor-mediated increase in cyclic AMP (cAMP) concentrations in T helper cells. | Cyclic AMP | CD4 molecule | Homo sapiens |
| 4 | Engagement of CD4 by peptide mimetics or wild-type MHC class II, but not by mutant MHC class II molecules incapable of engaging CD4, inhibited the T cell receptor-mediated increase in cyclic AMP (cAMP) concentrations in T helper cells. | Cyclic AMP | CD4 molecule | Homo sapiens |
| 5 | Full activation and clonal expansion of antigen-stimulated T helper cells required the CD4-mediated regulation of cyclic AMP. | Cyclic AMP | CD4 molecule | Homo sapiens |
| 6 | Our results suggest a costimulatory mechanism of CD4 function that acts on the second messengers, calcium and cyclic AMP. | Cyclic AMP | CD4 molecule | Homo sapiens |