Pub. Date : 2003 Jun 5
PMID : 12773039
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Common chemical features in the steroid and nonsteroid human CYP17 enzyme inhibitors, as deduced by the Catalyst/HipHop program, are one to two hydrogen bond acceptors (HBAs) and three hydrophobic groups. | Hydrogen | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | A model that permits hydrogen bond interaction between the azole functionality on ring D and the enzyme is consistent with experimental deductions for type II CYP17 inhibitors where a sixth ligating atom interacts with Fe(II) of heme. | Hydrogen | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |