Title : The effects of dentate granule cell destruction on behavioral activity and Fos protein expression induced by systemic MDMA in rats.

Pub. Date : 2003 Jun

PMID : 12767478






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1 In this study, we examined the effect of the s.c. administration of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) or saline on locomotor activity and Fos expression following the bilateral destruction of hippocampal dentate granule cells by colchicine in rats. N-Methyl-3,4-methylenedioxyamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 In this study, we examined the effect of the s.c. administration of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) or saline on locomotor activity and Fos expression following the bilateral destruction of hippocampal dentate granule cells by colchicine in rats. N-Methyl-3,4-methylenedioxyamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 In addition, when the lesioned animals were given s.c. saline or MDMA, there was a significant increase in Fos expression in the nucleus accumbens core, but not in the medial prefrontal cortex, dorsolateral prefrontal cortex, anterior cingulate cortex, piriform cortex, dorsal striatum, or nucleus accumbens shell, compared to the intact and sham-lesioned animals. N-Methyl-3,4-methylenedioxyamphetamine Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus