Title : Induction of hepatic DT-diaphorase in mice by butylated hydroxyanisole analogs: a structure-activity study.

Pub. Date : 2001

PMID : 12760486






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1 Induction of hepatic DT-diaphorase in mice by butylated hydroxyanisole analogs: a structure-activity study. Butylated Hydroxyanisole NAD(P)H dehydrogenase, quinone 1 Mus musculus
2 Butylated hydroxyanisole (BHA) and its analogs were evaluated for their relative activity to induce hepatic DT-diaphorase (EC 1.6.99.2) after dietary administration (at concentrations of 11.1 or 27.7 micromol/g diet for 3 days) to mice. Butylated Hydroxyanisole NAD(P)H dehydrogenase, quinone 1 Mus musculus
3 Butylated hydroxyanisole (BHA) and its analogs were evaluated for their relative activity to induce hepatic DT-diaphorase (EC 1.6.99.2) after dietary administration (at concentrations of 11.1 or 27.7 micromol/g diet for 3 days) to mice. Butylated Hydroxyanisole NAD(P)H dehydrogenase, quinone 1 Mus musculus
4 Of the compounds tested, only BHA and 2-tert-amyl-4-methoxyphenol, 4-methoxyphenols with 2-tert-alkyl side chains, were active in inducing DT-diaphorase activity. Butylated Hydroxyanisole NAD(P)H dehydrogenase, quinone 1 Mus musculus