Title : The same cellular signaling pathways mediate survival in sensory neurons that switch their trophic requirements during development.

Pub. Date : 2003 Jun

PMID : 12753092






3 Functional Relationships(s)
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1 The NGF-induced survival was completely blocked by either wortmannin (100 nM) or PD98059 (25-50 nM), which selectively inhibit the phosphatidylinositol 3-kinase-AKT (PI3 kinase-AKT) and mitogen-activated kinase kinase extracellular regulated kinase (MEK-ERKs) pathways, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one AKT serine/threonine kinase 1 Rattus norvegicus
2 The NGF-induced survival was completely blocked by either wortmannin (100 nM) or PD98059 (25-50 nM), which selectively inhibit the phosphatidylinositol 3-kinase-AKT (PI3 kinase-AKT) and mitogen-activated kinase kinase extracellular regulated kinase (MEK-ERKs) pathways, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one AKT serine/threonine kinase 1 Rattus norvegicus
3 In concordance with the survival assays, wortmannin and PD98059 blocked AKT and ERKs activation, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one AKT serine/threonine kinase 1 Rattus norvegicus