Title : Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF (+/-) mice.

Pub. Date : 2003 Jun

PMID : 12753073






4 Functional Relationships(s)
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1 In the brains of alcohol-naive mice, we measured [35S]GTP gamma S binding stimulated by the 5-HT1A receptor agonist (+/-)-8-hydroxy-2-dipropyl-aminotetralin hydrobromide (8-OH-DPAT; 1 microM). Sulfur-35 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
2 In BDNF (+/-) versus wild-type (WT) mice, 5-HT1A receptor-stimulated [35S]GTP gamma S binding was significantly attenuated in the median raphe nucleus. Sulfur-35 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
3 In the hippocampus, 5-HT1A receptor-stimulated [35S]GTP gamma S binding was significantly attenuated in BDNF (+/-) mice. Sulfur-35 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
4 5-HT1A receptor-stimulated [35S]GTP gamma S binding was attenuated in the anterior cingulate cortex and lateral septum, although these reductions did not reach statistical significance. Sulfur-35 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus