Title : TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.

Pub. Date : 2003 May 13

PMID : 12747827






7 Functional Relationships(s)
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1 We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1. tos ribosomal protein S6 kinase B1 Homo sapiens
2 We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1. tos ribosomal protein S6 kinase B1 Homo sapiens
3 We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1. tos ribosomal protein S6 kinase B1 Homo sapiens
4 We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1. tos ribosomal protein S6 kinase B1 Homo sapiens
5 We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1. tos ribosomal protein S6 kinase B1 Homo sapiens
6 We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1. tos ribosomal protein S6 kinase B1 Homo sapiens
7 However, it is unclear how the TOS motif in S6K1 and 4E-BP1 mediates mTOR signaling. tos ribosomal protein S6 kinase B1 Homo sapiens