Title : Hypoglycemic agent YM440 suppresses hepatic glucose output via gluconeogenesis by reducing glucose-6-phosphatase activity in obese Zucker rats.

Pub. Date : 2003 May 9

PMID : 12742522






1 Functional Relationships(s)
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1 Glucose-6-phosphatase but not fructose-1,6-bisphosphatase activity was reduced by YM440 and closely correlated with 14C-incorporation into blood glucose, indicating a key role for glucose-6-phosphatase in hepatic glucose output. Carbon-14 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus