Title : Stretch-modulation of second messengers: effects on cardiomyocyte ion transport.

Pub. Date : 2003 May-Jul

PMID : 12732268






3 Functional Relationships(s)
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1 Intracellular calcium-elevating agents such as the calcium ionophore A23187, the calcium channel agonist BayK8644 and the sarcoplasmic reticulum calcium-ATPase inhibitor thapsigargin up-regulate BNP gene expression. Calcium natriuretic peptide B Homo sapiens
2 Intracellular calcium-elevating agents such as the calcium ionophore A23187, the calcium channel agonist BayK8644 and the sarcoplasmic reticulum calcium-ATPase inhibitor thapsigargin up-regulate BNP gene expression. Calcium natriuretic peptide B Homo sapiens
3 Furthermore, stretch increases the activity of calcium-dependent effectors such as calcineurin and calmodulin-dependent kinase II, and inhibitors of calcineurin and calmodulin-dependent kinase II significantly attenuated stretch-induced hypertrophy and BNP expression. Calcium natriuretic peptide B Homo sapiens