Pub. Date : 2003 Apr 15
PMID : 12716916
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. | Morphine | hypocretin | Mus musculus |
| 2 | In this study, we show that orexin neurons, and not nearby LH neurons expressing melanin-concentrating hormone (MCH), have mu-opioid receptors and respond to chronic morphine administration and opiate antagonist-precipitated morphine withdrawal. | Morphine | hypocretin | Mus musculus |
| 3 | In this study, we show that orexin neurons, and not nearby LH neurons expressing melanin-concentrating hormone (MCH), have mu-opioid receptors and respond to chronic morphine administration and opiate antagonist-precipitated morphine withdrawal. | Morphine | hypocretin | Mus musculus |
| 4 | cAMP response element-mediated transcription is induced in a subset of orexin cells, but not MCH cells, after exposure to chronic morphine or induction of withdrawal. | Morphine | hypocretin | Mus musculus |
| 5 | Additionally, c-Fos and the orexin gene itself are induced in orexin cells in the LH during morphine withdrawal. | Morphine | hypocretin | Mus musculus |
| 6 | Additionally, c-Fos and the orexin gene itself are induced in orexin cells in the LH during morphine withdrawal. | Morphine | hypocretin | Mus musculus |
| 7 | Finally, we show that orexin knock-out mice develop attenuated morphine dependence, as indicated by a less severe antagonist-precipitated withdrawal syndrome. | Morphine | hypocretin | Mus musculus |
| 8 | Together, these studies support a role for the orexin system in molecular adaptations to morphine, and demonstrate dramatic differences in molecular responses among different populations of LH neurons. | Morphine | hypocretin | Mus musculus |