Pub. Date : 2003 May
PMID : 12707400
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G>A) and the glutamate carboxypeptidase 2 (GCP2 1561C>T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 2 | This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G>A) and the glutamate carboxypeptidase 2 (GCP2 1561C>T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 3 | Red blood cell folate concentration was higher in patients with the GCP2 CT or TT genotype (ANOVA, P = 0.04). | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 4 | A multivariate analysis confirmed that the GCP2 1561C>T genotype (P = 0.011) had a significant influence on the red blood cell folate concentration. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 5 | Overall, serum folate, creatinine, and the GCP2 polymorphism explained nearly 50% of the variance of red blood cell folate. | Folic Acid | folate hydrolase 1 | Homo sapiens |
| 6 | In conclusion, GCP2 1561C>T, but not RFC1 80G>A, is a predictor of red blood cell folate level in chronic dialysis patients. | Folic Acid | folate hydrolase 1 | Homo sapiens |