PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12706118-5 2003 We have found up-regulated levels of the cyclin-dependent kinase 2 (cdk2) protein in HDF expressing 143(ala) mutant p53 as compared to senescent controls, together with an increase in p21-free cdk2 which, in conjunction with cyclin E, is able to form an active kinase which can phosphorylate the retinoblastoma protein. Alanine 104-107 tumor protein p53 Homo sapiens 116-119