Title : The role of the enterohepatic circulation of bile salts and nuclear hormone receptors in the regulation of cholesterol homeostasis: Bile salts as ligands for nuclear hormone receptors.

Pub. Date : 2003 Apr

PMID : 12704471






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol catabolism to bile acids and feedback repression of bile acid synthesis, respectively. Oxysterols nuclear receptor subfamily 1 group H member 4 Homo sapiens