Pub. Date : 2003 Jun 27
PMID : 12697749
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | Here we demonstrate that constitutively active AKT2 renders cisplatin-sensitive A2780S ovarian cancer cells resistant to cisplatin, whereas phosphatidylinositol 3-kinase inhibitor or dominant negative AKT2 sensitizes A2780S and cisplatin-resistant A2780CP cells to cisplatin-induced apoptosis through regulation of the ASK1/JNK/p38 pathway. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | Cisplatin-induced Bax conformation change was inhibited by inhibitors or dominant negative forms of JNK and p38. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | In conclusion, our data indicate that AKT2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |