Title : Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice.

Pub. Date : 2003 May

PMID : 12697697






1 Functional Relationships(s)
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1 The present study shows that inflammation induced by im injection of turpentine (TPS) in the hind limb of mice causes an increase in the plasma concentration of IL-6, but not that of IL-1 alpha or IL-1 beta, together with a prolonged (>18-h) activation of the HPAA. tissue polypeptide specific antigen interleukin 1 alpha Mus musculus