Title : Two-step formation of 1H NMR visible mobile lipids during apoptosis of paclitaxel-treated K562 cells.

Pub. Date : 2003 Apr 15

PMID : 12694868






2 Functional Relationships(s)
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1 The present study shows that ML formation occurs at two different stages of apoptosis induced in human erythroleukemia K562 cells by a brief (3 hr) exposure to paclitaxel (Taxol), an antitumour drug with a stabilising effect on microtubules, or to paclitaxel plus tyrphostin AG957, a selective inhibitor of the p210(BCR-ABL) tyrosine kinase activity. Paclitaxel ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 The present study shows that ML formation occurs at two different stages of apoptosis induced in human erythroleukemia K562 cells by a brief (3 hr) exposure to paclitaxel (Taxol), an antitumour drug with a stabilising effect on microtubules, or to paclitaxel plus tyrphostin AG957, a selective inhibitor of the p210(BCR-ABL) tyrosine kinase activity. Paclitaxel ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens