Title : Contribution of bradykinin and nitric oxide to AT2 receptor-mediated differentiation in PC12 W cells.

Pub. Date : 2003 May

PMID : 12694402






6 Functional Relationships(s)
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1 Cellular cyclic GMP content increased by 50-250% with angiotensin II at concentrations of 10-6-10-4 m. Both blockade of AT2 receptors and of nitric oxide synthase markedly reduced angiotensin II-induced neurite outgrowth and cyclic GMP production. Cyclic GMP angiotensinogen Rattus norvegicus
2 Cellular cyclic GMP content increased by 50-250% with angiotensin II at concentrations of 10-6-10-4 m. Both blockade of AT2 receptors and of nitric oxide synthase markedly reduced angiotensin II-induced neurite outgrowth and cyclic GMP production. Cyclic GMP angiotensinogen Rattus norvegicus
3 Cellular cyclic GMP content increased by 50-250% with angiotensin II at concentrations of 10-6-10-4 m. Both blockade of AT2 receptors and of nitric oxide synthase markedly reduced angiotensin II-induced neurite outgrowth and cyclic GMP production. Cyclic GMP angiotensinogen Rattus norvegicus
4 Cellular cyclic GMP content increased by 50-250% with angiotensin II at concentrations of 10-6-10-4 m. Both blockade of AT2 receptors and of nitric oxide synthase markedly reduced angiotensin II-induced neurite outgrowth and cyclic GMP production. Cyclic GMP angiotensinogen Rattus norvegicus
5 Our results demonstrate that angiotensin II can stimulate cell differentiation in PC12 W cells by nitric oxide-related and cyclic GMP-dependent mechanisms. Cyclic GMP angiotensinogen Rattus norvegicus
6 The effects of angiotensin II on cell differentiation and cyclic GMP production were mediated via the AT2 receptor and further enhanced by bradykinin B2 receptor blockade. Cyclic GMP angiotensinogen Rattus norvegicus