Title : Preexistence and evolution of imatinib mesylate-resistant clones in chronic myelogenous leukemia detected by a PNA-based PCR clamping technique.

Pub. Date : 2003 May

PMID : 12692682






1 Functional Relationships(s)
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1 By combining peptide nucleic acid (PNA)-based DNA clamping with a fluorescence hybridization probe assay, we developed a new and highly sensitive technique for the detection of known mutations within the Bcr/Abl kinase domain. Peptide Nucleic Acids ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens