Title : Regulation of the cellular subpopulation ratios of normal human endometrial stromal cells by macrophage colony-stimulating factor.

Pub. Date : 2003 May

PMID : 12684699






4 Functional Relationships(s)
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1 Recently we found that macrophage colony-stimulating factor (M-CSF) inhibits 8-Br-cAMP-induced decidualization, differentiation to prolactin (PRL)-secreting cells, by suppressing viable decidualizing cells. 8-Bromo Cyclic Adenosine Monophosphate colony stimulating factor 1 Homo sapiens
2 Recently we found that macrophage colony-stimulating factor (M-CSF) inhibits 8-Br-cAMP-induced decidualization, differentiation to prolactin (PRL)-secreting cells, by suppressing viable decidualizing cells. 8-Bromo Cyclic Adenosine Monophosphate colony stimulating factor 1 Homo sapiens
3 A high concentration of M-CSF strongly suppressed the viable cell numbers and PRL secretion of stromal cells co-stimulated with 8-Br-cAMP and M-CSF, although G-CSF release from the co-stimulated stromal cells was not affected by M-CSF. 8-Bromo Cyclic Adenosine Monophosphate colony stimulating factor 1 Homo sapiens
4 These results indicate that M-CSF enhances G-CSF secretion from 8-Br-cAMP-unstimulated human endometrial stromal cells but not from 8-Br-cAMP-stimulated stromal cells, thus suggesting that there exists a functional subpopulation of G-CSF-secreting stromal cells that are different from the predecidualized ESCs that differentiate into PRL-secreting ESCs under stimuli with 8-Br-cAMP. 8-Bromo Cyclic Adenosine Monophosphate colony stimulating factor 1 Homo sapiens