Pub. Date : 2003 Apr
PMID : 12682486
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We examined whether gabexate mesilate inhibits tumor necrosis factor-alpha-induced expression of leukocyte adhesion molecules in cultured endothelial cells. | Gabexate | tumor necrosis factor | Homo sapiens |
| 2 | MEASUREMENTS AND MAIN RESULTS: Gabexate mesilate inhibited the tumor necrosis factor-alpha-induced increases in the endothelial expression of E-selectin and intercellular adhesion molecule-1 by inhibiting the transcription. | Gabexate | tumor necrosis factor | Homo sapiens |
| 3 | Tumor necrosis factor-alpha-induced increase in DNA binding of p65 was inhibited by gabexate mesilate through inhibition of the nuclear translocation of p65. | Gabexate | tumor necrosis factor | Homo sapiens |
| 4 | Gabexate mesilate inhibited the tumor necrosis factor-alpha-induced degradation of IkappaBalpha, an inhibitor of nuclear factor-kappaB, by inhibiting phosphorylation of IkappaBalpha in HUVECs. | Gabexate | tumor necrosis factor | Homo sapiens |
| 5 | Gabexate mesilate might reduce lipopolysaccharide-induced pulmonary vascular injury not only by inhibiting monocytic tumor necrosis factor-alpha production but by inhibiting the expression of endothelial leukocyte adhesion molecules. | Gabexate | tumor necrosis factor | Homo sapiens |