PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12682486-2 2003 We examined whether gabexate mesilate inhibits tumor necrosis factor-alpha-induced expression of leukocyte adhesion molecules in cultured endothelial cells. Gabexate 20-37 tumor necrosis factor Homo sapiens 47-74 12682486-12 2003 MEASUREMENTS AND MAIN RESULTS: Gabexate mesilate inhibited the tumor necrosis factor-alpha-induced increases in the endothelial expression of E-selectin and intercellular adhesion molecule-1 by inhibiting the transcription. Gabexate 31-48 tumor necrosis factor Homo sapiens 63-90 12682486-13 2003 Tumor necrosis factor-alpha-induced increase in DNA binding of p65 was inhibited by gabexate mesilate through inhibition of the nuclear translocation of p65. Gabexate 84-101 tumor necrosis factor Homo sapiens 0-27 12682486-14 2003 Gabexate mesilate inhibited the tumor necrosis factor-alpha-induced degradation of IkappaBalpha, an inhibitor of nuclear factor-kappaB, by inhibiting phosphorylation of IkappaBalpha in HUVECs. Gabexate 0-17 tumor necrosis factor Homo sapiens 32-59 12682486-17 2003 Gabexate mesilate might reduce lipopolysaccharide-induced pulmonary vascular injury not only by inhibiting monocytic tumor necrosis factor-alpha production but by inhibiting the expression of endothelial leukocyte adhesion molecules. Gabexate 0-17 tumor necrosis factor Homo sapiens 117-144