Title : Geldanamycin induction of grp78 requires activation of reactive oxygen species via ER stress responsive elements in 9L rat brain tumour cells.

Pub. Date : 2003 Jun

PMID : 12681446






3 Functional Relationships(s)
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1 The induced grp78 expression is sensitive to antioxidant N-acetylcysteine (NAC) addition, indicating the involvement of reactive oxygen species (ROS) in GA-induced ER stress. Acetylcysteine heat shock protein family A (Hsp70) member 5 Rattus norvegicus
2 The induced grp78 expression is sensitive to antioxidant N-acetylcysteine (NAC) addition, indicating the involvement of reactive oxygen species (ROS) in GA-induced ER stress. Acetylcysteine heat shock protein family A (Hsp70) member 5 Rattus norvegicus
3 The critical ROS-dependent elements in grp78 promoter can be confined within ER stress responsive element (ERSE) region, since reporter constructs loss of ERSE elements that lost the susceptibility to be modulated by NAC after GA treatment. Acetylcysteine heat shock protein family A (Hsp70) member 5 Rattus norvegicus