Title : Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders.

Pub. Date : 2003 Apr

PMID : 12675907






1 Functional Relationships(s)
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1 Here we report the novel finding that the enzymatic activity of PARP-1 promotes, in an beta-nicotinamide adenine dinucleotide-dependent fashion, the DNA binding of NF-kappaB in microglia exposed to lipopolysaccharides, interferon-gamma or beta-amyloid 1-40. nadide nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus