Title : Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells.

Pub. Date : 2003 May

PMID : 12675842






2 Functional Relationships(s)
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Protein Name
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1 The luciferase reporter gene assay revealed that indoxyl sulfate and indoleacetic acid dose dependently activated NF-kappaB and PAI-1 promoter. Indican nuclear factor kappa B subunit 1 Homo sapiens
2 Both antioxidant and NF-kappaB inhibitors dose dependently inhibited the activation of PAI-1 promoter by indoxyl sulfate. Indican nuclear factor kappa B subunit 1 Homo sapiens