Pub. Date : 2003 Apr 11
PMID : 12670496
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro assessment of inhibition by natural polyphenols of metabolic activation of procarcinogens by human CYP1A1. | Polyphenols | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | We compared the effects of 11 representative natural polyphenols, which normally occur in food, on different activities of CYP1A1, namely epoxidation of 7,8-dihydrodiol-benzo[a]pyrene, the terminal step in the activation leading to the ultimate carcinogenic diolepoxides, hydroxylation of benzo[a]pyrene, and EROD. | Polyphenols | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | The results demonstrate that the inhibitory effects of dietary polyphenols on CYP1A1 activity depend on both the structure of the inhibitor and the type of the reaction and substrate used in the assay. | Polyphenols | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |