Title : Inhibition of proteasome-dependent degradation of Wee1 in G2-arrested Hep3B cells by TGF beta 1.

Pub. Date : 2003 Apr

PMID : 12669309






2 Functional Relationships(s)
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1 The inhibitory phosphorylation of CDC2 on Tyr-15 was significantly elevated at 12-24 h, and its levels gradually declined during G2 arrest in Hep3B. Tyrosine cyclin dependent kinase 1 Homo sapiens
2 In particular, augmentation of CDK inhibitors p21cip1 and p27kip1 and Wee1 kinase and diminution of CDC25C phosphatase coincided with induced Tyr-15 phosphorylation and inhibition of CDC2. Tyrosine cyclin dependent kinase 1 Homo sapiens