Title : Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland.

Pub. Date : 2003 Jun 13

PMID : 12668683






3 Functional Relationships(s)
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1 TSH induced the PDK1-dependent phosphorylation of S6K1 but did not induce Akt/protein kinase B phosphorylation. Thyrotropin ribosomal protein S6 kinase B1 Homo sapiens
2 Rapamycin inhibited the phosphorylation of S6K1 in the cells treated with either TSH or 8-bromo-cAMP. Thyrotropin ribosomal protein S6 kinase B1 Homo sapiens
3 These findings suggest an interaction between TSHR and PI3K, which is stimulated by TSH and cAMP and might involve the downstream S6K1 but not Akt/protein kinase B. Thyrotropin ribosomal protein S6 kinase B1 Homo sapiens