Title : Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.

Pub. Date : 2003 Apr

PMID : 12657846






1 Functional Relationships(s)
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1 CYP3A inhibition decreases alfentanil clearance more than fentanyl clearance, confirming that the extraction ratio influences the consequence of altered hepatic drug metabolism. Alfentanil cytochrome P450 family 3 subfamily A member 4 Homo sapiens