Title : The role of polyol pathway in glucose-induced apoptosis of cultured retinal pericytes.

Pub. Date : 2003 Apr

PMID : 12639759






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1 These observations suggest that glucose-induced apoptosis in retinal pericytes, as one of the pathogenic factors of diabetic retinopathy, would be mediated through an aldose reductase-sensitive pathway including calcium-calpain cascade and increased oxidative stress, and that caspase-3 would be located furthest downstream of these apoptotic signals. Glucose aldo-keto reductase family 1 member B Homo sapiens