Title : Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor. Role of recombinant cytochrome b5 and P450 reductase.

Pub. Date : 2003 Mar

PMID : 12631293






3 Functional Relationships(s)
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1 Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor. Androstenols cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 In this report, we examine at the molecular level whether the enzyme 17 alpha-hydroxylase/17,20-lyase (P450c17), which possesses dual 17 alpha-hydroxylase and 17,20-lyase activities and catalyzes the production of precursors for glucocorticoids and sex steroids, is also able to catalyze the formation of a third class of active steroids, 16-ene steroids (including androstenol). Androstenols cytochrome P450 family 17 subfamily A member 1 Homo sapiens
3 Our results therefore demonstrate that human P450c17, as other enzymes of the classical steroidogenic pathway, is involved in the biosynthetic pathway leading to the formation of androstenol. Androstenols cytochrome P450 family 17 subfamily A member 1 Homo sapiens