Title : Src family kinases and nitric oxide production are required for hepatocyte growth factor-stimulated endothelial cell growth.

Pub. Date : 2003 Mar

PMID : 12618272






2 Functional Relationships(s)
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1 ERK1/2 and p38 MAPK were phosphorylated by HGF and a MEK inhibitor PD98059 and a p38 MAPK inhibitor SB203580 inhibited HGF-stimulated HUVEC growth by 66% and by 58%; however, HGF-induced phosphorylation of ERK1/2 and p38 MAPK was not inhibited by L-NAME, indicating that NO is not an upstream activator of ERK1/2 and p38 MAPK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one hepatocyte growth factor Homo sapiens
2 ERK1/2 and p38 MAPK were phosphorylated by HGF and a MEK inhibitor PD98059 and a p38 MAPK inhibitor SB203580 inhibited HGF-stimulated HUVEC growth by 66% and by 58%; however, HGF-induced phosphorylation of ERK1/2 and p38 MAPK was not inhibited by L-NAME, indicating that NO is not an upstream activator of ERK1/2 and p38 MAPK. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one hepatocyte growth factor Homo sapiens