Title : Role of postsynaptic density protein-95 in the maintenance of peripheral nerve injury-induced neuropathic pain in rats.

Pub. Date : 2003

PMID : 12617977






4 Functional Relationships(s)
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1 The rats injected intrathecally with postsynaptic density protein-95 antisense oligodeoxynucleotide every 24 h for 4 days from day 7 to day 10 post-surgery exhibited not only a marked decrease in spinal cord postsynaptic density protein-95 protein expression but also a significant reduction in mechanical and thermal hyperalgesia on day 11 post-surgery. Oligodeoxyribonucleotides discs large MAGUK scaffold protein 4 Rattus norvegicus
2 The rats injected intrathecally with postsynaptic density protein-95 antisense oligodeoxynucleotide every 24 h for 4 days from day 7 to day 10 post-surgery exhibited not only a marked decrease in spinal cord postsynaptic density protein-95 protein expression but also a significant reduction in mechanical and thermal hyperalgesia on day 11 post-surgery. Oligodeoxyribonucleotides discs large MAGUK scaffold protein 4 Rattus norvegicus
3 However, in the rats without nerve injury, postsynaptic density protein-95 antisense oligodeoxynucleotide given intrathecally every 24 h for 4 days did not affect responses to mechanical and thermal stimulation. Oligodeoxyribonucleotides discs large MAGUK scaffold protein 4 Rattus norvegicus
4 In addition, postsynaptic density protein-95 antisense oligodeoxynucleotide did not change locomotor activity of experimental animals. Oligodeoxyribonucleotides discs large MAGUK scaffold protein 4 Rattus norvegicus