Pub. Date : 2003 Feb 27
PMID : 12606032
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxidized glutathione stimulated the amyloid formation of alpha-synuclein. | Glutathione | synuclein alpha | Homo sapiens |
| 2 | The amyloid formation of alpha-synuclein was significantly facilitated by oxidized glutathione (GSSG) as the lag period of the aggregation kinetics was shortened by 2.5-fold from its absence. | Glutathione | synuclein alpha | Homo sapiens |
| 3 | The preferred GSSG interaction of alpha-synuclein to GSH was also demonstrated with dissociation constants of 0.53 and 43.5 mM, respectively. | Glutathione | synuclein alpha | Homo sapiens |
| 4 | It is suggested that the oxidative stress favoring the GSSG generation from GSH could result in the augmented amyloid formation of alpha-synuclein, which ought to be related to the pathogenesis of PD. | Glutathione | synuclein alpha | Homo sapiens |