Pub. Date : 2003 Feb 25
PMID : 12600921
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS AND RESULTS: This study investigated (1) whether and how endothelin-1 (ET-1), which is increased in DOCA-salt hypertensive rats, contributes to arterial superoxide generation and (2) the effect of gene transfer of manganese superoxide dismutase and endothelial nitric oxide synthase. | Desoxycorticosterone Acetate | endothelin 1 | Rattus norvegicus |
| 2 | METHODS AND RESULTS: This study investigated (1) whether and how endothelin-1 (ET-1), which is increased in DOCA-salt hypertensive rats, contributes to arterial superoxide generation and (2) the effect of gene transfer of manganese superoxide dismutase and endothelial nitric oxide synthase. | Desoxycorticosterone Acetate | endothelin 1 | Rattus norvegicus |
| 3 | Both superoxide and ET-1 levels were significantly elevated in carotid arteries of DOCA-salt rats compared with that of the sham-operated controls. | Desoxycorticosterone Acetate | endothelin 1 | Rattus norvegicus |
| 4 | The increase in arterial superoxide in both ET-1-treated normotensive and DOCA-salt rats was reversed by a selective ET(A) receptor antagonist, ABT-627, the flavoprotein inhibitor diphenyleneiodonium, and the NADPH oxidase inhibitor apocynin but not by the nitric oxide synthase inhibitor N(omega)-L-arginine methyl ester or the xanthine oxidase inhibitor allopurinol. | Desoxycorticosterone Acetate | endothelin 1 | Rattus norvegicus |