Title : Cyclooxygenase and cytochrome P-450 pathways induced by fetal calf serum regulate wound closure in 3T6 fibroblast cultures through the effect of prostaglandin E2 and 12 and 20 hydroxyeicosatetraenoic acids.

Pub. Date : 2003 Apr

PMID : 12599212






2 Functional Relationships(s)
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1 On the other hand, we show that ketoconazole, a cytochrome P-450 inhibitor, hinders the wound closure induced by FCS in wounded 3T6 fibroblast cultures. Ketoconazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 12 and 20 Hydroxyeicosatetraenoic acids (HETEs), which are key AA metabolites synthesized by cytochrome P-450, partially revert the effects of ketoconazole on the wound repair process. Ketoconazole cytochrome P450 family 4 subfamily F member 3 Homo sapiens