Title : Deletion of P1 arginine in a novel antithrombin variant (antithrombin London) abolishes inhibitory activity but enhances heparin affinity and is associated with early onset thrombosis.

Pub. Date : 2003 Apr 18

PMID : 12591924






1 Functional Relationships(s)
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1 The abnormal antithrombin was separated from the normal inhibitor by complexing the latter with thrombin followed by heparin-agarose affinity chromatography. Sepharose coagulation factor II, thrombin Homo sapiens