Pub. Date : 2003 Feb 25
PMID : 12590599
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Distinct effects on heparan sulfate structure by different active site mutations in NDST-1. | Heparitin Sulfate | N-deacetylase and N-sulfotransferase 1 | Homo sapiens |
| 2 | NDST-1 and -2 have a wide and largely overlapping tissue distribution, but it is not known if they can act on the same heparan sulfate chain. | Heparitin Sulfate | N-deacetylase and N-sulfotransferase 1 | Homo sapiens |
| 3 | Structural analyses of heparan sulfate synthesized by these cells and by cells overexpressing wild-type NDST-1 demonstrate that the N-deacetylation step is not only prerequisite but also rate-limiting, determining the degree of N-sulfation. | Heparitin Sulfate | N-deacetylase and N-sulfotransferase 1 | Homo sapiens |
| 4 | In addition, we show that oversulfation of heparan sulfate produced by cells tranfected with wild-type NDST-1 or the mutant lacking N-sulfotranferase activity results in decreased sulfation of chondroitin sulfate. | Heparitin Sulfate | N-deacetylase and N-sulfotransferase 1 | Homo sapiens |