Title : Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2.

Pub. Date : 2003 May 2

PMID : 12586835






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 In mitotic HeLa cells, when the activity of Cdc2 is high, S6K1 is phosphorylated at multiple Ser/Thr, Pro (S/TP) sites, including Ser(371), Ser(411), Thr(421), and Ser(424). Proline cyclin dependent kinase 1 Homo sapiens
2 These proline-directed phosphorylations are sensitive to chemical inhibitors of Cdc2 but not to inhibitors of mammalian target of rapamycin, phosphatidylinositol 3-kinase, MEK1/2, or p38. Proline cyclin dependent kinase 1 Homo sapiens