Title : Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation.

Pub. Date : 2003 Apr

PMID : 12586732






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 After 30 min of hyperosmotic exposure EGFR associated with CD95 and CD95 became tyrosine phosphorylated. Tyrosine epidermal growth factor receptor Rattus norvegicus
2 Inhibition of EGFR tyrosine kinase activity prevented CD95 tyrosine phosphorylation and DISC formation but not hyperosmolarity-induced EGFR phosphorylation and EGFR association with CD95. Tyrosine epidermal growth factor receptor Rattus norvegicus