Title : Identification of cytochrome P450 1A2 as enzyme involved in the microsomal metabolism of Huperzine A.

Pub. Date : 2003 Feb 14

PMID : 12586202






2 Functional Relationships(s)
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1 Result showed that 76.2% of Huperzine A metabolism was inhibited by CYP1A2 antibody and 17.8% by CYP3A1/2 antibody. huperzine A cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus
2 In conclusion, Huperzine A metabolism in rat liver microsomes is mediated primarily by CYP1A2, with a probable secondary contribution of CYP3A1/2. huperzine A cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus