Title : Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.

Pub. Date : 2003 Feb 18

PMID : 12576549






2 Functional Relationships(s)
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1 Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington"s disease. Vorinostat Histone deacetylase 1 Drosophila melanogaster
2 To further explore the therapeutic potential of HDAC inhibitors, we have conducted preclinical trials with suberoylanilide hydroxamic acid (SAHA), a potent HDAC inhibitor, in the R6/2 HD mouse model. Vorinostat Histone deacetylase 1 Drosophila melanogaster