Title : Effects of peripheral and central catechol-O-methyltransferase inhibition on striatal extracellular levels of dopamine: a microdialysis study in freely moving rats.

Pub. Date : 2003 Jan

PMID : 12573869






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Tolcapone is a mixed (peripheral and central) catechol-O-methyltransferase (COMT) inhibitor, whereas entacapone is a preferential peripheral COMT inhibitor. entacapone catechol-O-methyltransferase Rattus norvegicus
2 Tolcapone and entacapone, at the dose of 15 mg/kg p.o., were almost equally effective in inhibiting COMT activity in duodenum and liver. entacapone catechol-O-methyltransferase Rattus norvegicus