Title : Mechanistic studies on the interaction of reduced cobalamin (vitamin B12r) with nitroprusside.

Pub. Date : 2003 Feb 5

PMID : 12553836






2 Functional Relationships(s)
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1 At low pH and total NP concentration (pH < 3, [NP]/[Cbl(II)] approximately 1), the cyano-bridged successor complex [Cbl(III)-(mu-NC)-Fe(I)(CN)(3)(NO(+))](-) (1(s)()) is the final reaction product formed in an inner-sphere electron transfer reaction that is coupled to the release of cyanide from coordinated nitroprusside. Cyanides Cbl proto-oncogene Homo sapiens
2 At higher pH, subsequent reactions were observed which involve the attack of cyanide released in the electron transfer step on the initially formed cyano-bridged species, and lead to the formation of Cbl(III)CN and [Fe(I)(CN)(4)(NO(+))](2)(-). Cyanides Cbl proto-oncogene Homo sapiens