Title : Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts.

Pub. Date : 2003 Apr 11

PMID : 12547826






2 Functional Relationships(s)
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1 We found that induction of both c-fos and c-jun by arsenite can be substantially inhibited by the MEK- selective inhibitor U0126, suggesting that the ERK pathway is critically involved in their up-regulation. arsenite mitogen-activated protein kinase 1 Homo sapiens
2 Finally, chromatin immunoprecipitation assays revealed that arsenite treatment markedly induced the phosphorylation/acetylation of histone H3 associated with the c-fos and c-jun genes through an ERK-dependent pathway. arsenite mitogen-activated protein kinase 1 Homo sapiens