Pub. Date : 2003 Jan
PMID : 12545143
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dipyridamole enhances digoxin bioavailability via P-glycoprotein inhibition. | Dipyridamole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | BACKGROUND: On the basis of in vitro studies indicating that dipyridamole is an inhibitor for the MDR1 efflux membrane transporter P-glycoprotein, we postulated that dipyridamole could increase the bioavailability of digoxin, a P-glycoprotein substrate. | Dipyridamole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | BACKGROUND: On the basis of in vitro studies indicating that dipyridamole is an inhibitor for the MDR1 efflux membrane transporter P-glycoprotein, we postulated that dipyridamole could increase the bioavailability of digoxin, a P-glycoprotein substrate. | Dipyridamole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | BACKGROUND: On the basis of in vitro studies indicating that dipyridamole is an inhibitor for the MDR1 efflux membrane transporter P-glycoprotein, we postulated that dipyridamole could increase the bioavailability of digoxin, a P-glycoprotein substrate. | Dipyridamole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | BACKGROUND: On the basis of in vitro studies indicating that dipyridamole is an inhibitor for the MDR1 efflux membrane transporter P-glycoprotein, we postulated that dipyridamole could increase the bioavailability of digoxin, a P-glycoprotein substrate. | Dipyridamole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | BACKGROUND: On the basis of in vitro studies indicating that dipyridamole is an inhibitor for the MDR1 efflux membrane transporter P-glycoprotein, we postulated that dipyridamole could increase the bioavailability of digoxin, a P-glycoprotein substrate. | Dipyridamole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | BACKGROUND: On the basis of in vitro studies indicating that dipyridamole is an inhibitor for the MDR1 efflux membrane transporter P-glycoprotein, we postulated that dipyridamole could increase the bioavailability of digoxin, a P-glycoprotein substrate. | Dipyridamole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | MATERIAL AND METHODS: (1) The effect of dipyridamole on in vitro P-glycoprotein-mediated, polarized transport of tritium-labeled digoxin was investigated in Caco-2 cell monolayers. | Dipyridamole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 9 | CONCLUSION: Dipyridamole is an in vitro and in vivo P-glycoprotein inhibitor that increases intestinal digoxin absorption and digoxin plasma concentrations. | Dipyridamole | ATP binding cassette subfamily B member 1 | Homo sapiens |