Pub. Date : 2003 Feb
PMID : 12538809
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic nicotine treatment leads to sustained stimulation of tyrosine hydroxylase gene transcription rate in rat adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 2 | In previous reports, we have studied the mechanisms by which short-term nicotine treatment regulates tyrosine hydroxylase (TH) in adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 3 | In previous reports, we have studied the mechanisms by which short-term nicotine treatment regulates tyrosine hydroxylase (TH) in adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 4 | In this report, we study the effects of chronic nicotine treatment on adrenal TH gene expression. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 5 | Chronic nicotine treatment elicited long-lasting, dose-dependent increases in the levels of adrenal TH mRNA, TH protein, and TH activity. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 6 | Chronic nicotine treatment elicited long-lasting, dose-dependent increases in the levels of adrenal TH mRNA, TH protein, and TH activity. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 7 | Chronic nicotine treatment elicited long-lasting, dose-dependent increases in the levels of adrenal TH mRNA, TH protein, and TH activity. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 8 | In contrast, a single injection of nicotine elicited only a small increase in adrenal TH mRNA levels, which was transient and did not result in the induction of TH enzyme. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 9 | These results demonstrate that repeated nicotine injections administered chronically over 1 to 2 weeks lead to sustained stimulation of the TH gene and consequent induction of TH gene expression in rat adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 10 | These results demonstrate that repeated nicotine injections administered chronically over 1 to 2 weeks lead to sustained stimulation of the TH gene and consequent induction of TH gene expression in rat adrenal medulla. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |