Pub. Date : 2002 Sep-Oct
PMID : 12529972
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MATERIALS AND METHODS: To understand the mechanism of beta 2m-induced apoptosis, we added purified human beta 2m to cultures of K562 human chronic myelocytic leukemia cells, detected apoptosis by DNA fragmentation and annexin V binding assays, measured mitochondrial membrane potential (delta psi m), and used Z-VAD-fmk, a general inhibitor of caspases, inhibitors of caspases-1 and-3, as well as Western blot analysis to detect activated caspases. | benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | beta-2-microglobulin | Homo sapiens |
| 2 | Treatment with the general caspase inhibitor Z-VAD-fmk, as well as the caspase-1 inhibitor YVAD-CHO, significantly blocked beta 2m-induced apoptosis. | benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone | beta-2-microglobulin | Homo sapiens |